Exploiting the Interface of Biomolecular Engineering and Nanotechnology to Generate New Therapeutic Outcomes
Chemical and Biological Engineering
Rensselaer Polytechnic Institute
报告时间：2016年6月22日， 星期三， 下午1:30-2:30
报告地点：材料科学与工程学院 A楼 308
报告简介： Nature is unparalleled in its structural and functional diversity.In many cases, nature has provided us with a blueprint to design and assemble both natural and synthetic building blocks to create a new generation of functional, organized, and responsive materials. We have taken cues from nature to design materials with unique structural and functional properties, along with new process technologies with the ability to produce a wide range of biomimetic structures. In this talk I will highlight our recent efforts to exploit the interface of biology with materials science to address clinical applications. In particular, we have identified and engineered cell-lytic enzymes, and generated hybrid enzyme-containing surfaces with tailored activity against hospital-acquired infections (e.g., MRSA), food-borne illnesses (e.g., Listeria), and bacillus spores. Such activity provides a safe and potentially broadly applicable route to eliminating toxic compounds and pathogenic microorganisms from common surfaces. We have also developed a genetically encoded protein-based anoparticle-generating system for remote regulation of gene expression by low-frequency radio waves (RFs) or a magnetic field. This robust, repeatable method for remote regulation in vivo may ultimately have applications in basic science, technology and therapeutics.
Prof. Dordick received his B.A. degree in Biochemistry and Chemistry from Brandeis University and his Ph.D. from the Massachusetts Institute of Technology in Biochemical Engineering. He is currently a professor and also Vice President of Research at Rensselaer Polytechnic Institute. His research has included studies of Biocatalysis in Nonaqueous Media, Combinatorial Biocatalysis, Nanobiotechnology, enzyme technology, molecular bioprocessing.