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Andrew Whittaker教授 学术报告
发布日期:2018/9/27

报告题目: Biologically-Responsive MRI Agents

报告人: Andrew Whittaker教授,澳大利亚昆士兰大学

时间: 2018-9-27, 2:30~3:30

地点: 材料D楼312

联系人:朱申敏教授

报告人简介:

  Andrew Whittaker教授是澳大利亚昆士兰大学教授、澳大利亚生物工程和纳米技术研究所的高分子研究组负责人,澳大利亚研究理事会的Australian Professorial Fellowship,曾担任太平洋高分子联合会、澳大利亚皇家化学所高分子分会、澳大利亚高分子学会等的主席。2013、2014年获得中国国家外国专家局授予的全国高端聘请外国专家项目。2014年荣获高分子领域顶尖的Paul J. Flory Polymer Research Prize奖。该奖项于2000年由国际POLYCHAR委员会为纪念高分子界著名科学家、诺贝尔奖获得者Paul J. Flory而设立,用于表彰对高分子科学和工程领域的概念、模型、理论、过程或发现有原始创新和突出贡献的科学家。

  Whittaker教授长期从事磁共振成像诊断剂、高分子材料的合成与物理性能、以及在生物医用、印刷、食品等方面的研究与应用工作。尤其在高分子材料、磁共振成像造影剂等研究领域具有较深的造诣。近年来已主持澳大利亚研究总局科研重大项目等二十多项,科研经费4000多万澳元。已在国际学术刊物上发表高水平SCI学术论文260余篇。

报告摘要:

  Recently there has been intense interest in the development of fluorinated molecules to allow tracking of therapeutic particles and cells in vivo. The motivation for this is the very high selectivity of the 19F imaging experiment, since unlike in 1H MRI, the body does not contain a confounding fluorine background signal. In principle therefore, highly-selective 19F images can be superimposed on high-resolution anatomical 1H images, allowing tracking of suitably-labelled cells or biomarker molecules. Here I describe the motivation for the development of new partly-fluorinated copolymers with outstanding potential as 19F MRI imaging agents, and in particular as agents sensitive to the biological environment. The discussion will focus on partly-fluorinated macromolecules incorporating the monomer OEGMA which respond to external stimuli, for example local temperature, pH or ionic strength. I will also describe our programs in imaging and delivery to small animal models of glioma, the use of these molecules for tracking of therapeutic stem cells, and our investigations of mechanisms of cell uptake of nanoparticles.


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